Transcript of Webinar with Dr. William Walsh


Hello hello I see a lot of people starting to join. Welcome. Welcome to this Wednesday’s webinar on biochemistry in the brain. So as you are joining. I will want you to find the chat area. And as you find the chat, you’ll see the Q&A and the chat either of those will be fine. Sometimes it’s easier to use the chat so find the chat, and in the chat. I want you to just share with us what color of clothes you are wearing today. Are you a blue person, I’m doing purple today. Dr Walsh is that green or gray that you’ve got on.



Oh Grambling gray and blue there you go, probably should be red, white, that’s who’s got the Christmas colors going already. We do have a lot of reds,



Oh vetoes and red Leanna Hi, hello, hello. Nice to see you guys. And Heather’s got red for Christmas as well. Good. Oh, Carolyn I are doing the purple. It is, it has become my favorite color as well, which is interesting because I used to have blue is my favorite color and then it’s kind of shifted over the years to purple.



Very good,



and gray and blue does it count that I had an elf hat on for an earlier video call absolutely Emily, yes. Elf hats definitely count.



Very good olive green Alison I see you’ve got that on. Oh hi Jacqueline glad you can make it. You’re wearing blue today to Jennifer’s got blue on a lot of a lot of blues as well. Very good. Well, very nice to see you all, and I could not be more excited for today’s topic we’ll give people one more minute to join, and then we will start right at the top of the hour. Greetings Dorothy greetings from Canada, wearing blue but the room is very festive.



I like it. I like it,



we got to be festive this year. For many people, Christmas is gonna look very different so need to find and create meaning, and cheer where we can. Good. So for everyone else, logging in and joining us we are finding the chat because we will be taking questions later so I just want you to get familiar with where the chat is and how to type something into the chat, and you are just sharing with the rest of us what colors you are wearing today. And then we will get started. Western Australia Hi Peter. While logging in from Australia, yes,



You guys are starting this your day over there as well. Very good. All right, well it is top of the hour and we’ve got a lot to cover here. Hi Carrie, nice to see that you can make it today too. And I am wanting to introduce Dr Walsh, and he has been someone who has changed my life as I have shared with you guys in the emails, and that is because I started my journey after really having adopted my son from the foster care system and really struggling, challenged with all of his emotional and behavioral issues. And so this led me on my journey because obviously I was not finding the solutions from the psychiatrists and regular therapists, and the medications that they wanted to start him on were ones that were just going to sedate him and not really solve the underlying problem. So that’s really what started my search. In My search led me to a lot of different things including Dr Walsh and his book, nutrient power. And when I read this, it was just phenomenal the information and his clinical history and me also having a master’s in biochemistry. I absolutely loved the Science and loved what I saw like was being individualized in terms of knowing your biochemistry. So, Dr walls has been one of those people who professionally, I absolutely respect his work, and how he has done his work, and how he has changing in the field of psychiatry and functional medicine and bringing in this way to support our genetics, epigenetics, and tailor that through actual nutrients rather than medications, even though sometimes medications are helpful, and personally when I met him last year when I went out to be trained at the Walsh Research Institute. He is one of the kindest souls that I have ever met. And you, when you are in His presence, you can feel just how much he loves his work and he loves seeing the results of people’s lives being changed. And so it really is an honor to have you Dr. Walsh on this webinar today, and thank you for, for sharing your time with us.



Well, happy to be here.



All right, so we’ve got a lot, a lot to cover and I know that we’re not gonna be able to cover it all so I wanted to jump in and one of the things that we, that we are faced with is this concept of epigenetics, and we know that this has been a field that’s been developing, and really epigenetics influences so much of our health. And in particular, it’s helpful to look at that period of early development, and even pregnancy, and then you talk about, even before pregnancy and how important that period of time is in order to really set a healthy baseline for a person’s epigenetics. So could you walk us through that, Like, what is it that is put into play during pregnancy and even before pregnancy, that really helps set a child up for the emotional health, mental health and physical health.



Okay, starting with that.What goes on during the nine months of pregnancy is really quite extraordinary. It’s very complex, it’s so complex, that a person could not predict in advance. What a particular chemical or nutrient or drug might do. During the development of a baby, it’s that complex. There are literally billions and really trillions of combinations that might occur. However, we’re now getting to the point where we can actually find out exactly what’s happening. We’re doing cord blood studies. So I want to mention that. And somebody some smart people, about 10 years ago realize hey, the cord blood, your umbilical cord blood contains the DNA of the baby. So now they’re doing cord blood studies that are just absolutely fascinating where they’re they’re taking 10s of 1000s of expectant mothers, and maybe giving them plenty of, you might say folates or B12 or whatever, and they can determine exactly or quite accurately what the effect on the baby’s DNA in their epigenetics is. And I think that’s going to lead to a lot. One thing we’ve learned is that we know that folates are really well they’re given across the world to everyone, to make sure to avoid spinal bifida and some other nasty diseases. But what we’re learning is that yeah folates have a really powerful impact on, on the architecture of the brain, and on development, and if you have too little, you’re likely to have a child with, with a number of problems, serious problems. What we’re learning is that we now know that there’s a wide range of folate levels, genetically in human beings. And, and many mothers have by genetics have excessive amounts of folate. And if they get extraordinarily too much folate, it makes them prone to other disorders. So I think within five or 10 years, obstetricians are going to monitor their families. The mothers, and make sure they don’t have an excess because the surprising thing is that, folates and B12 given during the first early pregnancy. It causes undermethylation in the baby. It’s counter intuitive, but  it has a power effect. But the point I’m making is it’s really important, what the nutrients and really what the what the condition of the mother is, it’s the environment of the uterus, really. And we know that if the person has depression, or has great stress whether it’s emotional or even physical stress, that really affects the development of the child. And so we, I think we have a pretty good idea now, what needs to be done. Oxidative overload is something we don’t hear a lot, but it is something that can really damage, permanently damage and impair this child’s ability to function



Well of all the different stress the, the oxidative stress is really what damages the DNA the most, and really is, is kind of like that environmental insult that, along with the predisposition and the genetics causes the epigenetics, to start to develop symptoms and some of them can be irreversible conditions. I believe even like bipolar is one of the ones that you’ve recently looked into is, as one of those epigenetic conditions where along with the oxidative stress, that that’s kind of what sets that emotion, and it’s hard to reverse that once it gets started.



Right, um, for those who may not be totally familiar with it. We all know about how genetics effect people and certain conditions run than families. Well, the genetics strictly sort of defines the quality of the expressed proteins. We have about 21,000 genes, each one of them has a single job and has to express a protein or very few variants of that protein. And so every cell in our body is constantly nourished by these proteins. And, however, the DNA is the same in every, every cell in your body. And yet every tissue, every cell line has to have a unique composition. I think of it was like a restaurant, where you have this huge menu of the various proteins. And it’s not just the proteins themselves, but what really matters is how much of each one of those is produced in each one of the cells, and that’s what epigenetics. Epigenetics has to do the rate of gene expression. So, it explains, defines the quality or the structure or the quality of that protein. Epigenetics determines how much is made in each part of the body. So, the epigenetics we’re finding is often the cause of so many disorders, we know we know that schizophrenia, bipolar disorder, post traumatic stress. Some of these major, autism for sure, these major disorders are epigenetic. Epigenetics changes throughout the day. For example, I just had, my wife just made me dinner. The food I ate made changes in my epigenetics. In other words, it has caused some of the genes to express themselves differently. However, this happens all day every day, and even even emotional events, and illnesses at all. It changes your epigenetics. So what. However, most of this is transient, and easily reversed, and it goes away usually very quickly. Yep. However, if you have a sufficient insult. You can actually permanently alter your epigenetics,



What would be what would be an example of one of those insults that would cause permanent epigenetic changes.



Well, it has to do with DNA repair. Every one of our DNA is, and we’ve got, we’ve got roughly 25 trillion DNA. Okay. Every one of them, every day is actually ripped apart and damaged horribly about 10,000 times a day. And it’s really quite miraculous how the body, every cell actually has the ability to quickly repair it. Epigenetics an epigenetic disorder. And I use that term to be in a permanent condition, one that’s not going to go away. And this is when you have a sufficient assault on your DNA. That’s not repaired, not repairable. So then what you have is a permanent condition and the epigenetic disorder like schizophrenia or bipolar. One of the characteristics is rather sudden cases of sudden changes later in life. In other words, a person might be zooming along just fine in life. And then over a matter of a day or a week, dramatic changes, we might call it a mental breakdown. Or it could be an autism regression. Those are epigenetic conditions where the DNA repair cannot be recovered, and, and so it’s a combination of the oxidative assault. That tends to damage the DNA. And our machinery or ability to repair. Because genetically, when a person is born. Some people have really great innate protection against oxidative stress. Your body might produce glutathione and Matelathyine and on and on. We have an army of about 12 really wonderful natural antioxidants, and it only was a genetic expression. Well, some of us, some people. Like me. I’m one of



those that that does not do glutothione very well.



I had aunt that lived to be 109, and she was sharp all the way. Well, I think she had remarkable genetics for DNA repair. Yeah, also I think she had very good protection against oxidative stress, I think she just got lucky. And that’s why some families have longevity and others do not. Yeah, we know that aging, yes, it all has to do with DNA, integrity,



the protection of the DNA.



Because, from the day we’re born, our DNA begins to deteriorate a little by little by little, and that’s what aging is aging is changes in our DNA that’s nourishing ourselves, and the nourishment, become altered and and not as effective. And then, if you have a really major insult, which can be, which, which can be emotional or physical, we now know is there’s there’s solid published data showing that this can cause an epigenetic change. So basically overwhelmed



the body’s ability to handle that amount of oxidative stress and keep the DNA protected.



And so right, it’s right, and and the interesting thing is we have about 200 cell lines in our body 200 Completely different types of cells, and, and each one of them is like a different universe. And so you might have one part of your body that is better protected and better DNA repair than other parts of your body, which is why, when a person develops cancer, by the way, cancer is an epigenetic disorder.



Alzheimer’s dementia is an epigenetic disorder



that’s not completely clear but it probably is. Looks like it is. We have still a few people arguing about that. But anyway, that the, the, the, what’s was wonderful in terms of treating people with mental illness, is that we learned that we can use epigenetics, to help people. For example, if a person has low serotonin depression, which is very common. We now know that has to do with re-uptake and there is a gene called a re-uptake a gene called SERT, we can, we can change the expression of that gene. As an epigenetic therapy. So if we get a patient who has, who has low serotonin activity. Yes, you could help them with Prozac or Paxil or something like that, and they work by really on the SERT gene develops these proteins that go into your neuron membranes, and they’re the passageways for this thing called re-uptake, for the rapid return of neurotransmitters. After the cell fires. And so what Prozac does is it interferes with the function of those passageways. Those transport proteins. And and that’s why that can help people increase their serotonin activity and actually cure depression in many people. Well, we learned we could do it with nutrients. There are, In this case it happens to be methionine,  or Sammy. Yep. We’re sure people, most of you know about. And that causes a shutdown of that expression. So what happens is that your neurons don’t have as many of these passageways and inhibits re-uptake and it works, it really works very similar to a drug, but it has no side effects. And we’ve done this now. I would guess 20,000 times.



Yep, and I’d love to go deeper into this because the methylation is something that is, I mean so prevalent, right, like even in the general population it’s becoming more prevalent. Some people who are under methylators may not have symptoms from it always, but even just taking those people who experience some type of depression. It’s around 38-40% of them have under methylation.



I do want you to also touch on this idea that a person who has depression is not always going to respond well to an SSRI, right. Yes, with the under methylation, they do have the low serotonin activity. And so for those people, they may respond well to an SSRI, but then you have other people who are still presenting with symptoms of depression, and having a physician or provider start them on the first line of treatment and SSRI for an over methylator would not tend to have good results at all. So let’s talk about methylation and, and, first of all, like how did how did you even categorize. How did you find out that, that there’s over methylation and under methylation let’s start there.



Okay, it all starts with a great Carl Pfeiffer 50 years ago who was once nominated for a Nobel Prize for his work with schizophrenia, and he discovered that, that, in effect methylation had a lot to do with mental illness. And what he did that was I thought the reason why he was nominated for the Nobel Prize was he developed. He did the biochemistry and the neuroscience, and he discovered there were different types, different forms, he called them phenotypes of schizophrenia, in effect, schizophrenia is, he found is, at least five and probably six or seven completely different disorders, an umbrella term given to completely different disorders. Well, what I did is when I started doing clinical work and we started developing a huge database. In 1988 I had the world’s biggest database for methylation in human beings. And from that database, we also had more than 3000, cases of people with depression. So being a numbers person and being a scientifically oriented person. We discovered there are five completely different forms of depression, this thing called depression is not a single, you know, it doesn’t always mean you’ve got a serotonin insufficiency, right, and an SSRI will help you. That’s actually true about 40% of the time, 38 or 40% of the time. However, there are completely different disorders that could cause serious, you know, really serious depression, and, and we know what they are. And they involve different misbehaving neurotransmitters. They require different, unique individualized treatments. Exactly. So that’s how it started, and we’ve now been doing this for 30 years. And going forward, actually I was the first person to discover that methylation was really important in mental health back into the late 1980s, with autism, and I have the largest autism database in the world 5600 cases. And I used to meet with a group with the great Bernie Remland, who was sort of like the father and the godfather of alternative medicine or for for autism. For natural treatments of autism. and he invited me to his group that would be every six months from all over the world, researchers, clinicians, and he asked me to tell them about, about what we found in our database. And I’ll tell us really quickly. So we mentioned that, that they had almost all of them had a problem with a high oxidative stress. Yeah, we already knew that. They all said all we already know that they had a tendency for really high levels of copper and sort of low plasma, they already knew that. I mentioned that they were low in almost all the low in zinc. They knew that. So I went through all these things. And then at one point I mentioned, and also more than 98% of autistics are under methylated and the all said “What?” “What’s methylation got to do with anything?” So, we had to come back a couple of times, and then we located some world class experts on methylation. And they got involved with a group, and they proved scientifically it was true. So then methylation started to be something that people really began to focus on and then it expanded into other traditions.



Oh yeah, I mean, now they’re looking at methylation for addictions, They’re looking at methylation for PTSD, they’re looking at methylation, for so many different things and you don’t have to have necessarily a mental disorder to be under methylated right I mean some of these people are just You’re, you’re driven perfectionist perfectionistic health providers, right.



We’re learning that what we used to think was a serotonin insufficiency in terms of neurotransmission now we know that under methylation involves not only that, but to almost equal extent the NMDA react system Yes, the glutamate NMDA system. And that’s especially involving people who are having problems with OCD and addiction tendencies. We are now learning treatments to really help people with addictions. I think you’re familiar with most of them. We’re using things like a NAD riboside, because that often is the reason why the SAH or the SDSL homocysteine gets too high and that that seems to be as important as having enough methylfolate, for the rabbits, really. Yeah, we’re learning a lot.


Unknown 26:36

That and and also the N-acetylcysteine Dr .Walsh like that’s been really helpful for, I mean, a large amount of symptoms but especially in anybody with that high glutamate, if they’re coming, you know through detox and withdrawals from a substance and they’ve got that high glutamate, the N-acetaylcysteine has been really helpful for people who even just have the brain inflammation because they have primed microglia they’ve had a head concussion in their past and so they’ve got this tendency to have their brain, their microglia get inflamed that N-acetylcysteine is so helpful in just calming all of that excess, you know in NMDA activity down.



That’s a really interesting that we’ve known for at least 15 years, that they had glutathione levels were part of the dysfunctional nmba dance and Sal sustain has been studied for 15 or 20 years now, related to an MDA, and everybody thought, well, it’s one of the reasons it’s really helpful it’s because it’s a precursor of politici on exactly, but then we learned about six years ago something important that, yep. In acetylcysteine is an anti Porter. Yep, anti Porter, and at the end at the, the glial cells, the astrocyte cells that surround the, the nmba system, and it’s actually within those glial cells and that’s really where memory is formed. That’s where plasticity occurs. It’s actually where the neurons themselves were originally constructed during, during gestation



and it pushes the cooling into the glial cells.



So, and what’s really peculiar and really fascinating is that they learned that the N acetylcysteine are Anna Porter, Anna Porter beans that it reacts reacts with ions with an ion channel, and sends one chemical in one direction and the other in the opposite direction. It’s an anti Porter and what it does is it shoves more glutamate, into the synapse. Yep. And so far, in the beginning for a couple years, people thought, wow, this is increasing in MDA activity. Now, though it does the opposite. It is just fascinating. They know that all worked out. And the, it actually affects the presynaptic neurons and shuts down under a transmission. It’s just a beautiful biochemical situation. But now we know. And when that really became well known, we knew that we then we knew that it is sort of like a nutritional form of ketamine. Ketamine is something that can lower in MDA activity, and help people who have too much of it, like, for example, people who are under methylated primarily RFA certainly if they have addictions or C D and those kinds of things. It all has to do with a thing called memory extinction. We all have a flood of memories every second world online alert, like anybody looking at us now, see you and the things that your shelf and, but you have on



these are like the associations that our brain has made to help us survive. Right, I mean, its job is to form memories and to store those so that it can help us survive.



It’s been a mystery. One of the greatest mysteries I think in the world of science is what is member, even for God’s sakes, what is it, how many neurons are involved, how was the memory formed. We’re beginning to learn a lot of that has to do with projections on the Denverites. I’ll call conflict with any astrocytes. The nmba system. Yeah, so basically it is like yeah, which is why the the glial



cells become so important for supporting them because they’re the ones that are, they’re crucial in that neuroplasticity and rewiring, you know, pruning those dendrites, for the memory



of their learning, but the one thing they don’t know, maybe 15 years, is that these, these, these glial cells. We have about 80 billion of them equal number as we do neurons, and they form a network, and they have functions and things flow through the one getting full flows through them. I just read an article, it was published last week. Beautiful article on this very thing. And what they’re finding is that, that the every time a cell fires, of course, you have calcium ions that enter the cell and then are ejected back. Well, and what they find is that calcium, the memory of the cell phone fires neuron fires. It’s, it’s, it’s communicated through the whole brain. And so as we know, we’re all learning exactly home memories are in fact form it’s just fascinating. But memory gone wrong is really what OCD is the addiction is part of that. It has to do with memory extinction, we have to be able to get rid of the junk. Yep, we have to get rid of the junk. We don’t want people remember the rest of their lives that that nice little plant you have there, and how it looked. I mean, that’s nice, but that you don’t want to have that focus on people with OCD. Cannot, cannot get rid of the junk, and they tend to have these, you know, tendency just to repeat the same behaviors over and over, and I think severe OCD is one of the more challenging and difficult conditions I’ve ever encountered these poor people just, it just ruins their life going to courses epigenetic and every every one I’ve ever done, medical history on most every one of them talks about how it hit them all at once. Yeah. You probably get patients who said they could tell you the data the time when suddenly, that’s, that’s a mark of an epigenetic condition. A sudden change. For someone who had wellness, and suddenly they’re not well. And then the other Mark distinguishing mark of epigenetic condition doesn’t go away. Right. it doesn’t go away. Things like, it doesn’t go away, it’s going to go away easily. But if a person develops bipolar disorder that problem the rest of their life, despite all the aggressive therapies people have done for decades. Yep. And we’re learning all about this and I think it’s really exciting.



We are, we are learning so fast. Yeah, what we most of what we’ve learned recently hasn’t yet made it clinically, right, give us an ability to have superior premium programs, but, but even better prevention. Right. Prevention is easy for an epigenetic condition we now have the ability to detect. Yeah, we’re about to have a breakdown. We don’t we know that that most of the most epigenetic disorders occur when, When you have too much oxidative stress, and you damage, guanine, one of the four parts of your DNA code. And, and, you can now measure that in the blood.



Yeah, so if you, I think that’s going to be people, medical checkups, in the future. Yes, you’ll test that no tech, check for these oxidized guanine species, there’s so many good days that shows up in the bloodstream. And if you’ve got a high level that means Hey, watch oh you’re about to have a complete change and you might get like only change in your life, that might be cancer, heart disease, or a mental illness. Right,



well it’s telling you that your body is right at that edge of being overwhelmed. And so one more insult may be that one that pushes you over into that edge of the epigenetic conditions.



A few years ago I proposed that to autism, a big autism conference as a method to prevent autism. Then add fat soon after birth. Someone do a study and to see whether you’ve got too much damage guanine. Yeah, if you find a little baby. And by the way, most autism doesn’t begin doesn’t don’t either aggression usually took about 18 or 20 months. So when you find out before that you’ve got a child, you’re going to identify the children who are vulnerable. Yeah, we would just stuffed them with random antioxidants in it, and only has to do is do that until they’re three years old, or three years old, so they won’t develop autism because that’s a mental disorder. Yep. So anyway, it’s all fascinating. All right, well,



one question that I wanted to have you cover while we’re on the topic, and then, and then I need us to switch to talking about the other conditions so like the conference in ratio the payrolls, a little more about the methylation, but before we go to those. I’d love for you to address some of the epigenetic impact that we might be expecting from this year because it’s been a very stressful year for many, and some of the things that we can be doing in order to kind of be pulling ourselves, pulling our bodies back from that line of overwhelm. And what can we be doing for prevention. So I think that the answer is right like flooding ourselves with antioxidants because that’s the best protection for that B genetic conditions. So what are your top antioxidants, I’m assuming vitamin D, zinc, what else is on your list.



Okay, I think I think that the in terms of the body’s army of protective antioxidants, Lewis ion is perhaps number one, and and with respect to mental wellness uniquely different politici on Metalla fighting, which is an express protein and Mattel Athenian is something that the body automatically produces today, expresses if you’re able to fire levels are getting low.



It’s like four times of stress in selenium. Three Musketeers have antioxidant protection in the brain. And so certainly them now. Vitamin C is wonderful and E, vitamin D, to an extent vitamin A alpha lipoic acid and a seal assisting these this is a beautiful array, and they clever, they collaborate with each other. Yeah, exactly, position where you’re gonna say no it’s not functioning, you might be quite okay if everything else is compensating. Sure. Yeah, I think I think that’s, yeah, that’s number one. But what happens is that we look at America we have about 320 million people. And now that 300 million people. My guess is, we probably have 20 or 30 million people who back in February. We’re on the verge of depression, or some other illness, maybe even a physical illness, right on the verge of it. Well we know that oxidative stress is affected by stress. And we certainly had an amazing amount of stress of different times from from the people who have not yet taught that disease, the virus. and I’m sure that we’re getting something increased maybe even an explosion in some cases of depression, anxiety, and even the major disorders like bipolar and schizophrenia, I’m certainly incidence is increasing. And yes, you can protect yourself with antioxidants and that’s number one. But also you need to do need to do other healthy things and have a really nutrient rich solid diet, you need to exercise as much as you can avoid, you know, if you’re pre-diabetic do whatever you can to let that get, you know, get out of control. You just need to do the healthy things that, that we know we understand what to do. It’s not always easy to change a person’s lifestyle, but it will, it will make you healthier and you’ll enjoy whatever life you have, if you can.



Yeah, I think that we are already starting to see the beginning waves of that epidemic of mental health epigenetic conditions, and, and like you said there, there were a number of people who are already on that verge. And, and that’s what tipped them over and for other people it may it may take longer or it may it may have just been one, you know, more stress accumulated in their body and it won’t be the one that tips them over the edge, but it gets them closer to that edge for a later insult, but even just seeing what’s been happening in the mental health field over this last year, and even in the addiction field, I just got an email this last week from the medical literature saying that, looking at just the overdoses. This year Dr Walsh like they’ve already gone up 500% The overdoses. Yes, so, Yeah, we are we are we are starting, yeah there’s I am convinced of it there’s, there’s an epidemic of mental health, that, you know, includes the addictions, but it’s, it’s coming, because yeah like our lifestyles our world has changed and we are exposed to a lot more environmental stress, and then with our diet and everything, there’s a lot more internal oxidative stress as well and so it’s at baseline we’re closer to that edge of overwhelm for our nervous system in our DNA.



Yeah, I think, I think human beings, to have joy and happiness and feeling good and and and they need to have pleasure, and all the social pleasures pretty much evaporated. So, most of the enjoyment people have is being with other people. Right. So we removed all of that.



Yeah, which is the big protective factor, right like, another factor that tends to cause more. So yeah, exactly.



So that’s a good tie in into these other conditions because, you know, when we talk about living a healthy lifestyle and, you know, eating a healthy diet, many people will just automatically want to reach for a multivitamin.



And I know,  your opinions about a multivitamin, and I’ve had my personal experience where the multivitamin made things worse for me because of certain things that it had. And that was not good for me. So, speaking of which, like that let’s just jump in to the copper and zinc ratio, because that was something that I don’t think that I’ve shared this with you but when once I found your work and I tested myself, I had all three of those imbalances. I am a very, I am a very. Thank you like it, it actually did it gave me a lot more grace for how hard I feel like I have had to work in order to get through school and do well and and feel good,



your cable, that’s great.



I think I think that, I think that because I am such a strong under methylator, that that helped me compensate for the high copper in the payroll.



Yes. And right There are many things that but as you’re saying, it’s not just methylation methylation, about 70% of our mentally ill population that we’ve studied about 70% have a methylation imbalance. Yeah. However, there are other imbalances that you may have normal methylation, run great difficulty. Yeah, so copper metal, metal, metal metabolism to regulate copper and zinc is really important that I think that I think every doctor doing a devaluation of almost any patient really should run the lab tests for zinc and copper, especially,



especially zinc, I mean I would say that most people in our world right now are both zinc and vitamin D deficient of all the things that I test like those are the two that consistently, even in normal healthy people consistently come back low



mainstream medicine or 10 years ago discovered, vitamin D, you know, it’s wonderful because that was based on Dr are testing for vitamin D and normalizing it. Well, I’m sitting next to one they discovered zinc. Zinc is probably even more important.



Yes. Now



what a lot of people run into problems with though is that when they get the results back and they find that they have a higher copper ratio than than what is good and so they’ve got higher oxidative stress, They start taking zinc and things go bad. Yeah.



Talk us through that.



People have certain genetic, saying, there’s a, there’s a genetically expressed protein that is supposed to regulate our copper. Yeah, we’re so well it’s just, if you’re a normal human being with it in that regard. You could chew on copper bars all day long and your blood sugar level and be normal, because it regulates it beautifully. However, there are snip mutations in that particular protein, which is called the telephony. And, and so some people, I have a daughter who, by the way is a PhD. But she had, she has this problem, she has this extraordinarily high level of copper. And that has a dramatic effect on to neuro transmitters, tends to lower dopamine, which could cause ADHD and some people. But even worse that tends to increase norepinephrine. Yes, everyone so these people tend to be hyperactive, 68% of high copper, children are diagnosed with ADHD, and



then you have the postpartum depression right and 95% of ladies with postpartum depression right so it’s not just the hyperactivity, it’s, it’s some, some serious depression as well. What’s really insidious for postpartum depression is that



during a pregnancy. A woman’s copper level more than doubles, and that’s natural because the baby needs that for angiogenesis for growth, for, and anyway, so many patients have many patients that their loved children wanted children they’re married. The first baby came, and they had some trouble afterwards and then usually after the second or third baby, that they have full blown postpartum depression. In some cases, postpartum psychosis. Yes, I’ve had a lot of those cases. So what happened to them is the first time in their life, their copper escalated to a really high level, they were not able to bring it back down. So I got a study with Dr John Creighton University of Chicago, about 12 years ago, we published this in a peer reviewed journal. And we happen to have 800 women with with serious depression. So we compare those with postpartum depression. And those who had children, but never had postpartum depression. And it’s it’s common, it’s it’s what you said about 95% postpartum depression, patients, and elevated chopper in some of them had the condition, 20, and 30 years after delivery. You know there was a, it may not ever go down for these people. And when you read stories about about mothers young mothers who maybe might actually harm or even kill their babies. They are that’s, that’s who. These are people and we have postpartum psychosis. We, we’ve had quite a few patients with. But the good news is it can be quickly corrected. If you bring the copper onto the body. The average human being has 112, milligrams of copper in their body. These people have over 200. But as you were such, but you cannot do it quickly. So, copper person. And if you were, you were a high copper person, so you’ve experienced this. You don’t want to give the full dose of the treatment, to bring the copper out, because if you do, it’ll rural quickly you’ll have the highest copper levels in your brain in your blood, ever. You might



you will feel that



the worst day of your life. Yes, we learned that early and so our treatment is we get we just do it gradually and gently, we have maybe 1/3 or 1/4 the original dose. I’ve had some people that needed to get down to a 10th of the dose every other day. Wow, and just build up gradually to total tolerance. Yep. But it really,



it takes,



it can take so long to correct just because of how slow you may have to go.



However, it is probably the number one, highest efficacy, we get in any group of patients, we have, we have, it’s well over 90% Based on our job studies, and family, they not only get better but they stay better. Yep. The other group that we have great, great success with, believe it or not, are violent children. Yep, give us



the anger, the impulsivity rages



future six or eight years old. We we’ve done 10,000 violent children and adults, and our, we have our greatest success rate. We’ve published the efficacy of that twice. Nobody seems to notice it in psychiatry it’s think small. Don’t you really need a powerful drug to get the job done, they want to they want to do the psychiatric evaluations and find out whether they’re bad parenting or a lack of love, or traumatic experiences. Well I’ve had 10,000, patients with a problem, and just fix their chemistry and usually within two months they’re better exactly was the study in Australia, in a journal. A few years ago where we took 32 very violent, young males. And we tested them using psychiatric instruments that where you can where you can determine a person’s tendency for bad behavior. And we got p values of better than point 001 thing works. And one of my frustrations is trying to convince the field of psychiatry, of this and I’ve been trying to get money for a double blind controlled study, we’re ready to do it, but they’re expensive and right now, it’s usually we have difficulty getting the funding because the the institutions, whether it’s government or foundations, they’ll, they’ll ask maybe three people, three experts to evaluate the osdol. And usually there’s one little blackbolt saying, Well, it can’t it can’t be their bio chemistry. That has nothing to do with behavior, everybody knows it’s trauma or bad parenting, right, which was violent TV, or drugs, right, No, if you get them young enough. Exactly.



So that, and yes, there may have been these other things in their life, but I mean I have found that you can’t really even help them shift in any type of therapy work, any type of, you know sobriety recovery work without addressing the copper because they’re going to be reacting to that to that copper so that really needs to be part of the treatment plan. And then you can even have the bandwidth, the body can even be able to do the other work and respond to the other treatments.



Yeah. And when we’re lucky, we have a patient who is a great difficulty, and they only have one imbalance. Right, you’re pyrole disorder. And so yes, so



let’s talk about that next.



In some cases, somebody will be overloaded letter Berkery. So the individualization sort of thing. So the challenge for us and for you is when you get to see a patient with a problem is to identify what’s wrong, my thing is if it’s a mental illness, my focus is on identifying which neurotransmitters are misbehaving. Yep. Now we have therapies for normalizing or adjusting nerve transmission. Right. And I think we’ve, that’s why we’ve been doing better and better as time goes on, and better and better. The rehab new therapies that most people have never even thought of they’re really close, Right. Like messenger RNA. RNA piece where we like for example we do methylation therapies that can that can fix re uptake and help people with depression or oxidative stress, but the methylation therapies tend to affect maybe a dozen or 20 other genes so great side effects with with messenger RNA you could you could with the with the DNA code. Yep, proper protein, you could you could put that into the body, heavier body cells manufacturer, what you need. Yep, it’ll just pinpoint it and give it a side effects. I mean, that’s that’s going to be big in about 10 years,



right, this is the future is being able to identify your neurotransmitters and not just throw a medication at it but actually through nutrients, be able to change the epigenetic expression of their activity



is awesome okay another prop is something you mentioned early and that is that the population of the world is becoming more under methylated. Yes, and I believe it’s because the, the developed world, is giving huge amounts of flow forwards, both in families, and in prenatal vitamins in is causing the babies to become under methylated, and this is now gone through several generations. So it’s increasingly increasing. Yes, so what. So, in terms of schizophrenia, for example, about 15 years ago they discovered that most people with paranoid schizophrenia are the ones who hear voices and have that classic combination of terrible problems, they found out that most of them had too much dopamine activity in this, they discovered this by accident, they found that their children or people taking PCP that some of them can develop schizophrenia, and then it would go away with a PCP worse away and they they took a while before they realize what it was that it was actually the dopamine, that these are people with high dopamine, a beat at higher, you develop the schizophrenia from it. Okay. However, now we have, we have the candidate, the type of methylation in schizophrenia now is changing dramatically. It used to be at least 50%, or over methylated curve voices and all that sensory disorder. Now, it’s less than 10%. However, mainstream psychiatry continues to give the wrong medications me to get the right medications back 50 years ago, Right, as I needed to lower dopamine, but now they’re now they’re giving a typical anti psychotics every very blessed one of them, among other things, is focused on lowering dopamine activity that’s not their problem. Exactly, not the problem. There is a different class and I can understand why that’s hard for medical science to realize that in fact that the character of schizophrenia and other conditions has changed. That’s why so many people with addictions. Addictions are under methylated condition as well.



Yes. Oh, what I get frustrated at being in the medical field and I’m sure that with your work you get even more frustrated than me at this is that there’s still I see this tendency to with good intentions, be testing for methylation, but the way that they are testing for methylation imbalances is just by looking at the MTHFR gene. And that’s all that they’re looking at, they’re looking at Do you have a snip in that MTHFR gene, and if there’s a snip then they tell you that oh yes you have a methylation imbalance and their solution is to give you full eight, or, if, if, exactly, or if they’re really fancy they’ll want to give you methylfolate because you have a methylation imbalance, and this is not what is helpful for under meth laters in fact that’s going to make the, the, especially the serotonin, that you know the epigenetic changes on your DNA and how it expresses those transporters is going to make it worse. So I know that there’s lots of people here on this call who that has been kind of what they’ve seen done is just looking at MTHFR gene maybe through 23andme or some other genetic test. So, tell us, tell us the dangers of that and how that is so bad for under meth laters. Especially given that there’s such a higher prevalence now of under methylated ers.



Okay, one thing we’ve learned quite recently, and I don’t think I even presented this when you were at our session. We’ve learned that, that, under methylation is associated with low serotonin activity, excessive glutamate activity. We’ve learned and we have these symptoms and traits people who are under methylated tend to be



very Be very gentle here now to wash remember that I am a strong under methylator. So, be kind to me, be kind to me as you describe me



know. There are many wonderful aspects of being under methylated and a few names, yeah. But the point is that we’ve don’t treated 15,000 or more people with under methylation. Right. Guess what, These traits of competitiveness tendency for seasonal allergies. On and on these classic traits. Most of them don’t change. Right, I’ve had great athletes who were very competitive I worked with, with professional athletes, and they were all worried about changing normalizing their methylation when I explained it had a lot to do with competitiveness they’re afraid they would no longer be elite athletes. No, not at all. So what does that tell you, it tells you that it’s not the one carbon cycle. It’s not the methylation cycle, it’s not the MTHFR what it really is, Is the methylation, the degree to which your DNA has been methylated. Yep. That’s what determines every epigenetics really involves a gene that has methylated as as as a methyl molecule, near it. Yeah, on your DNA strand, and these are called Biffle bookmarks, and they, and that’s how gene expression is adjusted for different tissues in different parts of the body.



So let me check in with the audience right now so for those of, for those of you who are listening. He just said something really really important in terms of methylation, and that it’s not the MTHFR gene it’s actually how much methyl groups are on your DNA, if that makes sense if you got that if that clicked in your head and when you type in the chat and got it, so that we know that we’re all on the same page. If there’s still some, some things that are not clear about that let me know but if, if you got that piece that it’s not MTHFR, it’s the actual how much methyl groups are on your DNA. That is what determines your methylation status,



and also where they are. You might



where they are on the DNA exactly,



it’s a very variable, they call it differential DNA methylation and and so if you’re under methylated that we know you’re under methylated if we if we do our testing we can we can we can identify a person who has a poor Sammy slaw ratio when we can do that. However, what it really, if you’re if you’re if your body biochemically is that are methylated. It means your DNA is under methylation and the DNA. So what happens with with under methylation, for example, if you’re under methylated and you happen to have depression, which is the major form of depression, low serotonin activity, depression. If you gave, they’re under methylated, but full age. And, and, and methyl Sammy and Floyd have opposite effect in their DNA. Methyl tends to shut down gene expression. fully increases gene expression now boasts Floyd and Sammy and the thigh name, are, are nothing laters. Really powerful myth laters. Problem is, some of these methyl laters. If you’ve got to disturb methylation cycle, Some of these nutrients that we use some, some of them falling for example, will tend to lower serotonin activity, which is the worst thing you can do for someone with that, or even something later that is the worst thing you can do. Most people with OCD and majority of people who are prone to addictions are under methylated, and they will get worse if you give them points, not be there their methylation will improve in the body and the patient will get worse, because of the effect on DNA and gene expression.



Okay, so say that one more time because that is so key. You give them schooling, you give them methylfolate eight



methyl folate age,



the methylation status may improve but they will get worse. That’s what happens. So many of them. Hey, did everybody get that. Let me know if you got that.



Yeah, for you to access it if you’re really for the scientists out there for a fact as we get settled ACE inhibitors. They have the inhibits sirtuins, and this has an advance, we know exactly what happens. And and it affects jeans differently. So, the, the net effect of giving the whole folate, folic acid or folic acid any of them to a person with low serotonin activity is you’re going to drive their serotonin activity. Further down the benefits you get from improving methylation are found, overwhelmed by the dramatic decline in their serotonin neurotransmission. Yep, we learned that the hard way, we’d learned that the hard way for 1000s and 1000s of patients. It’s wonderful to go there. I’m a little bit. I’m very bothered by some of my colleagues who don’t seem to appreciate this and as soon as they find a person has a homozygous 677 T snip on their MTHFR they think aha, This person needs methylfolate



he answers methylfolate, it could kill them. Yes,






Yeah. On the other hand if you’ve got, if you’ve got a autistic child who might be under methylated and not have a serotonin problem. It might help them, and probably would. Or if you’ve got, there are people who are over methylated, that’s what’s really interesting over methylated people thrive on foliage.



Yes, yes, it’s like this miracle, it just, it takes over and they like their symptoms, dramatically decrease. I’ve been very happy with it now, I don’t get many over meth leaders anymore. Right. I get four minutes, so I get far more under meth laters. But for those over meth leaders, it’s been wonderful.



Yeah, so we’re getting in schizophrenia, we’re getting a lot of people who have delusional disorders. They’re everywhere. They have this breakdown and they have this terrible condition called schizophrenia. And it’s really a completely different form of schizophrenia, it’s the under methylated version. Yep, scientists like to call it, hypo methylation. Hypo and hyper REM Yep. Over 100 right now.



All right well I’m watching the time Dr Walsh and I promised you that I would have you out by an hour and we’re already over an hour. So, if you don’t mind. Let’s jump quickly to pyrole disorder. Talk about that because there’s been a few questions about that, and then I will let you go and I will talk with the audience about exactly how to test for this stuff, and their next steps. So with the primal disorder. I mean there’s so much here as well. But what I would love for you to talk about is one, is it also an epi genetic condition that is triggered by stress. And if so, can you use it as a marker for how stressed, the body is, and what are some of the symptoms that a person would know that they or their child or patient they’re working with have pyrole disorder.



Okay. The good news is that player will disorder is not empathetic, and the reason is the way we know that it’s, it’s correctable a pyrole disorder can cause great harm to a person. And and it usually affects them from the time they’re very young, but it’s correctable a full blown epigenetic conditions are not correct, not readily correctable. But what it amounts to is it’s a, it’s a genetic. It can be either genetic and reversibly learned that it’s because it really is a measure of marker for oxidative stress. And, and, in the biochemistry of what goes on in your bone marrow and on to a different, some degree in your spleen. The, the biochemical reactions that involve, or maybe synthesis of hemoglobin and some of those blood chemicals. If there’s excessive, if a person has too much oxidative stress, it can it can produce payrolls, no payrolls are byproducts of all these reactions like might be A plus B gives me a woman plus payrolls plus maybe somebody else. Well the payrolls have though, it’s a byproduct of regular important reactions payrolls have no function in the body and the body just clears them out it goes out in the bloodstream and then out in the air. Yep, Cron is they have affinity for zinc and BC six yep affinity for anything is an aldehyde B sex is in the form of P five p is the major aldehyde in the bloodstream, and it strips these things out. So if you’re really in so it’s a double deficiency, or at least a double depletion of zinc can be sex and runs in families. I had a family and her, where they had a history of extreme violence for many generations. This woman at SunJin children. They all had pyrole disorder. Oh my gosh, it was a wild household. And they did really well. Although a couple of them had become unfortunately schizophrenic before, before it got corrected pyrole disorder itself can cause. Just the methylation imbalance. So with pyrole disorder is my favorite imbalance reason is, it’s, it’s present in about 10% of the population, and people with mental illness, it’s more like 20 or 30%. Autism is between 35 and 40% of autistics are had plural disorder, and almost anyone who has pyrole disorder gets better, if you treat it. The beauty of as they get better, it’s something that can usually be completely corrected. All you have to do is normalize basics, and zinc.



And it’s one of the ones that respond the fastest.



Yes, yeah on children I wait, I did, I worked with more than 10,000 violent people also worked with EX convicts and criminals.



Only while you were so calm, Dr wash.



I spent a lot of time with criminals I spent 18 years actually as a prison volunteer, trying to help people in prison. And I, the first few people I got to know well and spent a lot of time with were actually death row inmates. And yeah you. I’ve learned to listen and be



well enough and that’s probably why I love I love. I think why you’ve been able to accomplish so much in this work is because you worked with the hardest of the hardest people right like and if you can improve their brains and their neurotransmitters, then for the rest of us, you can definitely optimize us



started with violent children and violent adults, to try to understand why they were violent, that it really was biochemical, most of us born, it can be, it can be aggravated by a bad environment. Sure, I’ve tested people in the inner city in Chicago and people in wealthy suburbs, and, and if they if you get to a child with a inborn tendency for violence. If they’re in the wealthy suburbs and they have caring parents and a good environment AYP Okay, at least mild cases of it in child in the inner city where there’s violence and there’s a bad environment. Yeah, poor diet, stress, they’re likely to wind up in prison. It’s the same. But it’s so it can be aggravated by life experience. However, it’s, I think one of my greatest disappointments as I’ve gone to. I told the told us the United States Senate to the Surgeon General, I published the this I’ve gone to California corrections, Illinois corrections. Nobody will believe it. They think it has to do with bad parenting or something, or trauma. No we I really believe we could really make a dent in crime and violence, maybe really bring it down 80 90% If you simply would take young children identify their tendencies their genetic biochemical tendencies for violence, which will usually involve zinc deficiency pyrole disorder, possibly elevated copper and things of that nature. And, and they just get better. But you have to do it before they’re before they get into drugs and alcohol. I tried at the beginning to turn some of my some of my ex convicts and get into the system. And I found that we had very poor success with them they would get better than we’d find out later that they, that they stopped taking a treatment. And what happens is that they I think they, they, once they’re past the age of 12 or 13 or 14 Once they start committing crimes, it’s very hard to help them. They also get involved heavily with drugs, and they have substance abuse problems. Anyway, that’s



the problem right because then, then there’s this whole other host of changes that happened to their nervous system that are very hard to undo. After that,



I made a study of sociopaths, I worked with hundreds of them. It broke I’ve been we’ve interviewed and tested for Charles Manson and some of the world’s most famous criminals. And, and, and what science is finding, first of all their chemistry is striking and the sociopaths have a single combination of balances that is really unique. And what we find is that they find that they have smaller, a big doors, the amygdala in your brain is a part of the brain where you have empathy. And they, when they see a person’s face, the sociopath does not recognize a frown or as part of the condition it’s really interesting, but it’s, it’s so much that it is by an inborn biochemical and correctable we’ve had, we’ve had hundreds of sociopathic wild children. I mean really wild violent children won’t be violent 10 times a day. And they do well. And I still hear from some of them 30 years later, and they’re still doing fine, as they were probably headed for the penitentiary. So that’s kind of my biggest, I guess that’s my biggest frustration of the remedy to convince people, And since I felt I could not convince. I couldn’t convince the governments or or scientists or the mainstream. I decided the only way to do this is, is by training, lots and lots of doctors and have them do this, and develop, maybe 10s of 1000s of cases of kids getting better. If I had a bumper sticker my bumper sticker would say, well, when, when, When the people with the people we. The leaders will follow. Yeah, so he had to do it from that and because I did everything I could to convince with data, with science. Nobody wanted to listen. Yep.



However, the treatments do work. And in March, we’re gonna have our next physician training program.



Thank you. I was just gonna say so if there are people in the audience who are providers, and so are in a position to be trained, tell us about your next training because I cannot recommend it more based on just my own experience and how much it’s done, not only for my life but then for being able to help others.



My goal 10 years ago was to train 1000 Doctors throughout the world. Yeah, we’re gonna hit 1000, in March.



Oh my goodness, how meaningful. Wow.



I started giving presentations at the annual APA meeting, American Psychiatric Association have a meeting. And the first time I went there I told them they were doing depression all wrong, explained how there are these different types of depression. Since that time we’ve been flooded with psychiatrists coming through our training I think we’re probably close to 80 to 100 psychiatrists, they’re our most enthusiastic, doctors,



well they finally give solutions,



say and say, it’ll be a fight, I think it’s like a six week program. And we know do it virtual. We did our first virtual training last October.



Yes, and good job at it I have to say



it was Dana on our staff is a wizard at this sort of thing, and she did a beautiful job. And so we did the full training, including evaluating real patients and going through the whole process of medical history. Medic, looking at the lab results, design, diagnosing the imbalances in the treatment, design, over and over and over. We did that virtually worked out well. Yes, we’re gonna do it again starting in, in March we just put up the notice for anyone who is interested to get information, do this, and



I’m sending people to the Walsh Research Institute, is that the right place to send them to for information on the screening, okay



ultra, and we’d be happy to send whatever information we have our website is full of information and lectures and want lots of information, and, and the textbook is our book, nutrient power.



Yes, which I highly recommend all of you get a copy of that.



It’s not only on eight different languages. It was a bestseller for a while in Germany and it wouldn’t went really well in China and Japan. So that’s been no it’s the book is eight years old, but it’s still I think very relevant. I’m just finishing another book, I hope to have it out in about two or three months. I believe that I’ve discovered the actual cause and mechanism mechanism of bipolar disorder. And I sort of stumbled on it to tell you the truth, but it’s right there in all the neuroscience literature is coming out, there’s an explosion in neuroscience throughout the world. And it was right there so that’ll be in the book, I’ll send you a copy of



it, please do because it has to do is like the electricity of the of the neuron cells right



so epigenetic disorder. And what happens is you get sufficient enough of an insult, chemical, or emotional where suddenly your, Your, your gene expressions change, and let’s what happens in cancer, you might lose a broken gene for example that was functioning, but in the case of bipolar, you lose some of the genes that have to do with enabling our neurons to have high voltages are, we have 80 billion neurons. They’re tiny little guys, but if you can string them together somehow from one to the voltage of a flashlight battery, what a battery. They would be amazing. But anyway, that’s, we are born naturally humans are born with the ability for that to happen, and that’s why we function so well we do cognitively. But if, if the epigenetics weakens that system, then their, their, their, their voltage of their of their neurons drops, and that causes hyperactivity, and then that I’ve learned, hyperactivity and bipolar is the cause of bipolar depression that depression, really well. Yep. Anyway that’s coming. So what did we miss not know I just want to mention to anybody watching this, if there’s anything that we failed to answer or I didn’t answer properly, Skype, contact Dr. Amy, I think she understands all of this. And she,



well they thank you for your confidence. Yes, and I will be sticking around you guys to specifically talk to you about how to test for these imbalances and happy to give more information about the training if you have more questions about that as well. And I see that some of you have asked more questions. So yes I will be sticking around to answer those questions, Those, those are some really good questions about the glial cells and the undermount methylation. So, Dr Walsh, thank you so so very much. Like I say you are a hero of mine and it is truly an honor to be able to know you and see the work that you’re doing to help so many people.



Well, I wish you the best Dr Amy and wish continued success. I’m really glad you’re spreading the word.



Then my 23andme, but I don’t go to that for my methylation status, I go to that to know, like Dr Walsh and I talked about, like my gluta silane status.



Do I have the genes that are making healthy D pacification system. Do I have any problems with absorption. And so for my 23andme That’s how I found out that I do not absorb vitamin D very well.



Okay, good to know. Maybe that’s why I’ve always had really low levels. And that’s why I hate such high amounts now and I track it so that I know that I’m taking the right amount, but without the 23andme. I would never have put those pieces together, of my glutathione and vitamin D, so the 23andme is useful in many ways, but not methylation status you cannot look at your MTHFR gene, and know what to do. So, if, if you are you have a loved one who has done that MTHFR gene test



using whatever test, and there is a snip, and they have been put on methyl folate or some form of full eight. Just be cautious, right, because that’s, as he was talking about today, that’s where things can go worse where sure the full eight is a, is a methyl donor so your overall methylation status will improve. But what happens is that the serotonin level activity is low. And so your symptoms of low serotonin, primarily OCD type of symptoms and depression symptoms,



those are your biggest symptoms for low serotonin, those can get worse. And usually get worse with that full eight because it affects the serotonin activity and actually decreases it even more.






So I’m seeing questions of, yes there will be a recording I will definitely send that out. And if you are already treating with zinc and P five p which is P five p is the activated form of basics. And that’s a really good point. So I’ll come back to that. Do you recommend stopping prior to testing, yes. So when you take these tests, you should stop all supplements three days before you test. That’s all you need to do is this three days before you test. In order to get the most accurate results. If you are taking any form of medication that would influence your whole blood histamine levels. So the most obvious would be any kind of anti histamine, but saying that there are, there is a long list of medications that influence histamine levels, most of the mood medications influence histamine levels. So my general rule of thumb is that hey you know if you’re on any kind of medication, it might affect the whole blood histamine levels. And just to make sure we actually are going to get the results that we need. Let’s do the methylation has through doctors data rather than da j so that we can be looking at that methylation status and not relying on histamine because that may not be an accurate marker. If you are on



medications. Okay.



And another question that I saw come in was in regards to the physical symptoms, not just mental or emotional symptoms of some of these conditions. And so, that is still under study. Obviously Dr Walsh’s work has focused on the brain and so emotional and behavioral disorders. But what many people are finding many providers are finding, and there’s a whole group of us that that once you get trained by the Walsh Research Institute, you’re part of this group where they, they share a lot of information and so a lot of them are sharing that they are seeing more types of chronic fatigue, especially in those people with the high copper and the payroll disorders, which makes sense because with both of those, you have a much higher incidence of the oxidative stress. Right and so that is, that is what really kills your mitochondria and your mitochondria are the biggest factors in chronic fatigue, because your mitochondria are the factory houses for making energy. And so that would make sense that in those two conditions. The energy production would be most effective. And so affected. And so that’s where you’re seeing those types of symptoms show up so the muscle aches, right, that’s all a mitochondrial issue, and it’s just the matter of determining figuring out what is causing the mitochondrial issues, there can be a long list of things, right, Lyme mold toxins. Deficiencies nutrient deficiencies, stress, the oxidative stress, there can be a long list, but I’ve been able to identify what are the problems causing the mitochondrial inefficiencies, is going to be crucial to identifying and feeding the root causes of the physical symptoms. So, from my experience chronic fatigue was something that I had to experience as part of my health crash, and it was not enough just to start supplementing and and doing the targeted nutritional plan that’s part of this, even though that helped us so many other things. I also then had to bring in the mitochondrial piece, and so he mentioned in AD, right so in AD is something that I think most of you know that I do a lot of and that was a huge game changer for me for my health and helping my money laundry I’d be able to make energy and make it more efficiently, but then I’m also doing all the other things I’m doing a lot of antioxidants, I’m doing you know all of his list which I’m not sure if you guys are able to write down his list of antioxidants very fast. All of those are things that you should be taking anyway if you have the copper overload or you have the pyrole disorder because you need to be hitting your body hard with antioxidants, having those disorders those imbalances, puts your body closer to that edge of overwhelm. And so one more environmental insult, whether it’s, you know, something that is an exposure to COVID an exposure to 5g and exposure to bad food or an exposure to an emotional insult, any of those would be enough then to just be that additional insult that will push your body over the edge. If you’re already that close. So those are two conditions that you should know if you have, right, go and get tested, know your biochemistry, so that you can be addressing it and preventing any more insults that would trigger another epigenetic condition for you. And does the DA J link also work for Canadians yes so you can order that test for being in Canada, there will be additional shipping charges that the lab will work out with you, but you can definitely do that in Canada and lipid ZOMO methyl B 12 Does that address low methylation. So, for under methylated years, there are the essential targeted nutritional supplements that you’re going to date, and then you’re going to have helpful supportive supplements, so B 12 is one of those helpful supportive supplements, not one of the essentials. If you are under methylator. And let me see if I have of that list right here near, near me on I did under Miss laters traits. Calm exterior, but very high anxiety inside. This can also be where you have strong habit strong routines they can even go into that OCD being some obsessive type of stuff,



competitive perfectionistic self motivated in school, strong willed controlling seasonal allergies because of the high histamine High Achiever accomplished. I am reading I’m literally reading the list off of, you know what he gives us in the training. Good response to SSRIs SSRIs which were the two antidepressants that I was on. And also, then, you know, had to be very intentional in supporting and this is, this is the protocol that I use to help myself get off of those antidepressants, so I know that I know that I know that this stuff works right because I’ve had to do it myself, bad reaction the full eight, and that’s where, you know, don’t go and just take a multivitamin because full eight for under methylator is not going to be a good idea. The the multi most multivitamins have fully so you even need to watch your B vitamins, if you’re taking a B vitamin complex, make sure that it does not have full eight, If you think that you might be an under methylator. And if you think that you might be in under methylator, go and get tested, right. This is, this is something that you want to know for the rest of your life to know how to support your body rigid dietary habits, more introverted, doing more solo sports, again, like he said most people with addictions are under methylated ers. And these are people who tend to be oppositional, and he has found that the underneath leaders are the people who tend to not stick through with the, with the targeted nutritional plan right they even if they don’t start to feel better, they just tend to be oppositional and you’re not going to tell me what to do. And so they don’t, they don’t follow through, they don’t actually do the their treatment plan. So that’s, um, those are all the traits that can be part of under methylation. And so if you are an under methylator You’re going to want to take a methyl donor. In order to help with that epigenetic because you’re because we’re actually working on the epigenetic level, it takes time to experience that shift. It’s not going to be the immediate effect where you’re immediately blocking the reuptake of serotonin you’re actually changing it on the DNA level, changing how your DNA is expressed to make more or less of certain proteins. And so the usual response time is three to four weeks and can be even out to six weeks to really see the benefit of raw



epigenetic changes that will happen when you start taking a methyl donor. Your methyl donors are Sammy, that’s what I use. So every day, every day, I am taking 400, or 800 milligrams of Sammy. And I do that every day, not because it helps me that day but because it’s gonna create that different baseline for my epi genetics. So it’s important for me to maintain consistent. Consistency on that so that I can create that, that new baseline epigenetic change in my methylation status. The other methyl donors are refining, so for many people, if we’re working with a kid if you have a child, and they are under methylator, which a lot of the kids that I work with, when they are adopted when they have had those types of life experiences, it changes their methylation status and most of them are coming back as under meth leaders I’ve only had one over methylator, and she was very she was very violent, she was very aggressive she was very physical and responded very nicely to the full eight. But for the rest of them, they’ve all been under methylated ORs. And so the meth finding is a much easier. Methyl form to give to children. Your other methyl donors are going to be the TMG so for some people they use like the butane and TMG, and that also helps with a little bit of the stomach acid and digestion, that many people can have. And so that can be another form of the methyl donor that you can mix with pick at the, at the same time along with the Sami or the refining. Everything else is supportive, those are your essentials your essentials are the methyl donors, everything else is supportive. And so this would be the antioxidants, so the supportive ones include calcium under methyl eaters are actually low in calcium. But you should be taking it with magnesium, and because of the higher inner stress, and the nervous system, being more tense, then you definitely want to be taking more magnesium because you’re going to be more deficient in magnesium. So, under methylator should be taking their methyl donor calcium and magnesium together be six especially if they have high homocysteine and then B 12 So, I definitely, if we’re working with under methylation I definitely would say yes take methyl B 12 Rather than just a regular b 12, and I would definitely take that as well. And then you can take other things right like the inositol is really good, especially for anxiety, your antioxidants so your vitamin A or vitamin E, vitamin C, always vitamin D. And then, even your diet so under meth lighters do much better on a higher protein diet.



And so, for most of my life, I was not eating in the right way and I felt awful. So once I once I learned all of that, it was. Yeah, I mean it’s it’s been, it’s been huge. And then the other interesting thing for my diet, which was very different. I grew up being very much told how important breakfast was is the most important meal of the day. And for those people with behavioral disorder, like me, they tend to have nausea in the morning. And so understanding that and being able to support my body in that and now I do mostly. He’s bulletproof type of teas with MCT oil sometimes with collagen protein. And then even my some of the mushroom powders. So Lion’s Mane I’ll mix in with all of that tea and I will do that in the mornings because I don’t feel like eating breakfast, and I no longer feel guilty about that, because I have found how to do the nutrients, and that’s just kind of where, where my body’s at with, with its with its pyrole disorder and conditions.



How does one peak with mercury toxicity and. Okay, so with the mercury toxicity that’s going to be causing more oxidative damage, so you’re going to need to hit, not only the anti Austin’s more but you’re also probably going to need some form of correlation. And there’s different degrees of correlation so doing depend on your system and how sensitive it is, you may need to do a more gentler correlation so I like to use Seido detox. I’ll put that in the chat here. I like to use Cyto detox for those people who need a more gentler Ulation for heavy metals like mercury. And



let’s see.



So with their. These are really good questions you guys should under methylator Avoid full late supplemented foods. Yes. Under meth laters should avoid forms of enriched foods that have full it, some people who are under methylated ORS will be able to not even tolerate those foods that are naturally containing foliate, so this would be even things like spinach right spinach is one of the foods that’s higher in full eight thumb under meth laters cannot tolerate that. Well, it really depends on everything else that you’re doing. Once they tart, once they start taking a methyl donor that sometimes will change and they’ll be able to start taking an eating whole late foods, but still, I would definitely stay away from any of the fully enriched foods. We talked about that at the very beginning, where, because of the issues with infants, and the neural tube defects that can happen in those babies during their pregnancy where the mothers are fully deficient. That was the reason for the US government, starting to enrich grains with folate, was to address the neural tube defects. But as he said, we’ve kind of swung the opposite direction. And now we’re actually getting more of fully than what is what is healthy and what is good for most infants, and so they are actually being born under methylated



Alright you guys, I am watching my energy level I’m watching my voice and realizing that I am I am nearing done here. So let me share with you the links again. And I will be following up with you on a masterclass for these imbalances, and how to navigate them. The supplements to take when to test how to test, and all of that, so I will be getting back to you on that. In the meantime, if you are ready to test. Then, let me put that link in again, and you are welcome you guys, I love you guys so much. Okay, so there is the link if you want. If you are ready to order the test, you can order the test yourself you don’t actually need a provider to order the test for you. So there is the link for you to be able to go to the DOJ website and order the tests yourself. Now, if, if you are wanting someone to review your results with you and give you the you know like the treatment the targeted nutritional protocol, then I am happy to meet with you and go over those with you. For those of you who would who would like that. I’m going to put the link in the chat right now to make an appointment with me. For some of you, you may not know yet whether you should even get tested. And for those people. I would say make an appointment with me. We can talk about it because not everybody needs to get tested. There is so much that we can go off of symptoms and history, that it may be more beneficial to start there, and we may not need to be testing right away. So either way, if you are ready to order, go ahead and do that and then you can make an appointment with me in order to review your results show go over your targeted nutritional treatment program and what that would look like, walk you through exactly what supplements to take what dosages, what to look out for, I’m happy to walk you through that process, and that. Yeah, like we may even just create a whole masterclass around everybody who wants to get tested, and then we can all walk through that together, and walk through the different challenges and as a group, be able to show you, this is exactly what you do. And then you have the link there and brightens your mind needs to decompress it was so hot. It’s a lot. So for those who are international, I would say that the best thing is make an appointment with me so that we can figure out do you need the testing and how would we do the testing, and you have. Yeah, you have the links there for ordering those, and for making an appointment with me. Any other questions about that, does anybody need the links, again. And what links do you need the testing, great question. I want to say Leanna that the testing costs, $298 for all three. So you’re ordering the metabolic panel, which is going to be all three the methylation status. Copper and Zinc ratio, which includes Cirilo plasm because we need that to calculate the copper zinc ratio, you don’t need to understand that just know that that’s part of the test, and then the pyrole disorder which is the urine test. So for all of that. That is the 298,



I believe,



is anybody on the website right now that they can say the price melody is saying that it’s 266. And currently I believe that the yes, the, if you’re in the calendar to schedule an appointment with me. It should be adjusted to your timezone. I’ll look at that yes they did, They, they gave you a special prize for ordering, or ordering through this, through this webinar. So yeah, normally the price is $298 you guys and they are offering it at $266 for you. That is so awesome, I love them,



they, they have



honestly been the best lab that I have ever worked with in terms of customer service and I have worked with a lot of labs over the years, so I’m not sure whether this is just like an extension of Dr Walsh and his kindness and his calmness that the lab is run this way, but, but they really are the best lab work customer service that



I’ve ever worked with.



Okay, the you. So Kathleen I’m seeing that you are looking for the link for Dr Walsh, I don’t have that link on me. So what you will do is you will Google Search Walsh Research Institute. And that is where you can find out more about his health provider training. And I think it’s limited to physicians, and I think it’s limited to physician so in these indies, maybe nurse practitioners as well but I think that they have to be working under a physician, But for any of you who are in the audience in and fit that category and want that training,



I cannot recommend



it highly enough, it’s it’s really changed. Changed my practice is obviously changing psychiatry, so if you are in any of the fields of trauma, addiction, mental health, or even, you know, health and performance, because those were not things that, you know like I would have related to at the time, this is definitely something that you want to understand more about. So I would definitely look into his book, nutrient hour. And if you are able to attend the training. Thank you. Thank you, Bobby, thank



you. Kira, I



appreciate that.



Providing the links Thank you. And how long do you have to go off of medications before you test. So, Melissa, this is where it may not be a good idea to go off of medications. Medications more than supplements, create longer effects on the biology. And so if you are on or if a person is on any regular home, medications, then it may be best to order the test through doctors data for the methylation status. So that would be something where I would say maybe we should chat first, maybe we should have a discovery call first talk about your specific situation, what medications you’re on, if that requires the other test, or this test, and go from there because I would still want you to test for the Keto payrolls I would still want you to test for the copper and zinc.



But, we may need to troubleshoot the methylation, before jumping in and saying which test to get what I say to wait until pathways are open before any testing. I’m not sure what you mean by pathways are open. I would say that if you are one of the people who are in the brain inflammation course so tackling brain inflammation, we are starting a course January for, and if you are in that course, you should really, really strongly consider doing this testing. Now, because there was no way that I was going to be able to fully tackle my brain inflammation and tell, I knew that I was dealing with copper overload and all of this oxidative stress from the pyrole disorder, and had my neurotransmitters off from the under methylation, as well. So, this is going to be an important piece for tackling brain inflammation so anybody who thinks that they may have brain inflammation, one we are doing a course on that and we’ve got the video library that you can have access to. And you can also choose to join us for the three weeks of that guided course in January, and definitely be considering doing these tests, because this will definitely play a big role in. Yeah, in whether you have, what some of the root causes for the brain inflammation that if we don’t address, you will get stuck in.



All right.



I coordinate with Dr. Daniel Amen. So I actually took my son to get the PET scanning with Dr. Amen and started becoming very familiar with their work and their protocols, I love him to death. I love what he does. And, at least for me and my son it was not the full picture. So, again, don’t take what I’m saying wrong, I love Dr. Amen, and he has helped so many people and really changed the world of Psychiatry in terms of actually imaging the brain and yes you can see my dog, cat out of the corner she’s



letting me know that, that it’s time to go, it’s time to feed her.



So, with Dr. Amen. He does amazing work. And so, oh you’re gonna come say hi to people and he does amazing work, but he doesn’t, he doesn’t do these biochemical imbalances, he doesn’t do the neurotransmitters. You know, he looks at the the the rings of inflammation in the brain. And so this was a piece, the this testing these imbalances was a piece that really helped move the dial for for my son and myself. So do I coordinate with Dr. Amen. No, not in that sense, but it’s definitely part of it’s part of the bigger picture in terms of all the different approaches and tools that we use to address the brain. All right, hey, I have, I’ve got to go now. In order to conserve my energy. Thank you for joining me tonight. And let me make sure that you have everything that you need. Does anybody need anything else, you will be getting the link for the recording. And you guys are very welcome. You have the link to order the test if you want to go ahead and do that. And I know that Jacqueline we had talked about it and I think that we’re doing it when you come back to the mainland to save on some shipping costs. So we’re looking into that. And then you guys have the link to schedule a meeting with me, if that would be of most benefit to you, so we can talk through things and help you figure out your next best step for crackling, your issues.



Everybody has everything that they need. Alright, well then, have a very good night you guys, and know you can schedule now if you want best you can schedule so what happens is that they send you a kit, it gets there within a week there, they have a very fast response rate. Once you send in the sample, I have those results within five days, so it’s a pretty fast turnaround as well. And so, if you are wanting to schedule an appointment then I would, I would do that now I think I only have my schedule out until the middle of January. So I would, I would schedule now to make sure that you get one of those spots. If you are interested in them. And you guys have, have that link.



Alright, have a very good night, you guys. Love you all.